There are numerous sources of liver damage, but only one associated with the use of oral prohormones or anabolic steroids -- cholestasis. Cholestasis is defined as a failure of bile to reach the duodenum, which could be due to a number of different pathological states between the hepatocyte and the ampulla of Vater. When somebody takes oral prohormones (especially 17-AA ones) the physical structure of the hepatocyte is changed -- microfilaments and canaliculi become less contractile. Changes in the canalicular bile salt export pump may also occur. This leads to decreased bile flow and the retention of highly toxic hydrophobic bile salts. At low levels, these bile salts cause apoptosis; at higher concentrations, tissue death and serious liver damage. This is where AEGIS comes into the picture. It was designed with users of oral prohormones in mind, and brings together the best anti-cholestatic nutrients bar none.